I think that you are lost in your settings and that you forget the main thing which is not to have fun with tons of parameters but to have an effective generic solution for the majority of users who want to quickly put a video on Youtube and get a good quality.

The normal user is not going to do this, he will be content with the complexity of the settings of software like Handbrake. I do not see the point of doing 4:4:4 starting from 4:2:0 which is largely what is more popular on Youtube. GTX1650 (original) with GPU TU117 4Go GDRR5 GTX 16x0 and RTX cards have almost same performance and quality for encoding, The object of the discussion is not the encoding speed which I consider sufficient with Nvenc. No, the GTX1000 series is not the most efficient for the quality / weight ratio since it does not support B-Frames for HEVC.

I'm talking about the weight / quality ratio for Youtube destination, so by also considering upload time which is a problem for many people, therefore lossless formats are irrelevant.

Handbrake vs adobe media encoder